GSK2807 Trifluoroacetate

Name	GSK2807 Trifluoroacetate
Synonyms	CS-2876 GSK2807 TFA GSK2807 Trifluoroacetate (S)-2-Amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(dimethylamino)propyl)amino)butanoic acid 2,2,2-trifluoroacetic acid salt
CAS	2245255-66-5
EINECS	604-604-1

Molecular Formula	C21H33F3N8O7
Molar Mass	566.54
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
In vitro study	A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (K i =14±6 nM and 345±36 nM, respectively).

biological activity	GSK2807 Trifluoroacetate is SMYD3 effective and selective, SAM competitive inhibitor with Ki value of 14 nM and IC50 of 130 nM.
target	SMYD3 14 nM (Ki) SMYD3 130 nM (IC 50 )
in vitro study	A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (K I = 14±6 nM and 345±36 nM, respectively).

Last Update：2024-04-10 22:29:15

Product Name: GSK2807 Trifluoroacetate Visit Supplier Webpage Request for quotation
CAS: 2245255-66-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: GSK2807 Trifluoroacetate Visit Supplier Webpage Request for quotation
CAS: 2245255-66-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

GSK2807 Trifluoroacetate

GSK2807 Trifluoroacetate Request for Quotation